https://orcid.org/0000-0001-8056-6634
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ABSTRACT
Purpose
It was aimed to assess the role of thiol-disulphide homeostasis and ischemia-modified albumin (IMA) level in the development of diabetic macular edema (DME) in patients with diabetes mellitus type 2 (T2DM).
Materials and Methods
Sixty-six study patients were divided into two groups. Group I included 43 patients with T2DM and DME, and Group 2 included 23 patients with T2DM without eye involvement. A novel colorimetric method was used to assess thiol-disulphide homeostasis. Between the two groups IMA, total anti-oxidant, and total oxidant levels were measured and compared.
Results
In Group 1, total and native thiol levels and disulphide levels were lower compared to Group 2 (p = .025, p < .001 and p = .013, respectively). Disulphide/native thiol, disulphide/total thiol ratios and native thiol/total thiol were similar between the groups. Total anti-oxidant level (TAL) reduced whereas total oxidant level (TOL) increased in Group 1 compared to Group 2 (p = .001, p = .002, respectively). Albumin level decreased, whereas IMA level increased in Group 1 compared to Group 2 (p < .001 for both).
Conclusions
The disruption in thiol/disulphide homeostasis, increased IMA and oxidative stress have an impact on the development of diabetic macular edema.
Abbreviations
Authors’ contributions
All authors made substantial contributions to conception and design, acquisition of data, or analysis and interpretation of data; took part in drafting the article or revising it critically for important intellectual content; gave final approval of the version to be published; and agree to be accountable for all aspects of the work.
Authorship
All authors attest that they meet the current ICMJE criteria for authorship.
Consent
Written informed consent was obtained from the patients and their families before any examination or treatment was performed.
Conflicts of interest
The authors report no other conflicts of interest in this work.
Declarations
Approval was obtained from the Istanbul Süreyyapasa Chest Diseases and Thoracic Surgery Training and Research Hospital ethical review committee (October 4, 2017 and Decision number: 012).
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.