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Abstract
Attempts were made to elucidate lethal responses of hepatocytes of Japanese eel (Anguilla japonica) exposed to Krebs-HEPES buffer at different concentrations of Cu++ and Zn++. It was found that the 2-hr LC50 value of Cu++ and Zn++ on eel hepatocytes was 490 and 1576 μM for Cu++ and Zn++ in single solution, and 1734 and 5200 μM in mixed solution. the toxic effects of Cu++ and Zn++ on eel hepatocytes were characteristic of antagonistic interaction. After 2-hr exposure, the amount of accumulated metal on the hepatocytes and the mortality of hepatocytes were increased with increasing metal concentration in Krebs-HEPES buffer. the accumulated amount of both metals was significantly decreased when the eel hepatocytes were exposed to mixed metals than to single metal.