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Abstract
Obesity is a risk factor for being diagnosed with asthma, but there is conflicting evidence on whether obesity is a risk factor for lung function abnormalities characteristic of asthma. We studied a cohort of 488 subjects, 47% of whom were obese. Obese and non-obese subjects with asthma had similar airflow limitation and bronchodilator responsiveness, but obese participants had increased sleep disturbance and gastroesophageal reflux disease, higher cytokine levels, and a trend towards increased exacerbations when treated with theophylline. Obese and non-obese asthmatics have similar lung function abnormalities, but comorbidities and altered responses to medications may significantly affect asthma control in obese people.
| Abbreviations | ||
| ALA-ACRC: | = | American Lung Association-Asthma Clinical Research Centers |
| ASUI: | = | Asthma Symptom Utility Index |
| BMI: | = | body mass index |
| CRP: | = | C-reactive protein |
| FEV1: | = | forced expiratory volume in one second |
| FVC: | = | forced vital capacity |
| GERD: | = | gastroesophageal reflux disease |
| IL6: | = | interleukin 6 |
| LODO: | = | “Effectiveness of Low Dose Theophylline as Add-on Treatment in Asthma” |