Case Report: Allergic Bronchopulmonary Aspergillosis and Allergic Fungal Sinusitis Successfully Treated with Voriconazole

Abstract

Allergic bronchopulmonary aspergillosis and allergic fungal sinusitis are closely related disorders that rarely present in the same individual. The mainstay of treatment for allergic bronchopulmonary aspergillosis is systemic corticosteroids. Itraconazole is used as adjunctive therapy in refractory cases. Allergic fungal sinusitis requires initial sinus surgery followed by systemic steroids. Antifungal therapy has not proven to be beneficial in allergic fungal sinusitis. We report a case of concomitant allergic bronchopulmonary aspergillosis and allergic fungal sinusitis that was refractory to standard therapy but had dramatic clinical response following treatment with voriconazole.

Keywords:

• allergic bronchopulmonary aspergillosis
• allergic fungal sinusitis
• asthma
• antifungal agents
• corticosteroids