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ORIGINAL ARTICLE

Fetal Sex and Maternal Asthma Control in Pregnancy

Ludmila N. Bakhireva Division of Pharmacy Practice and Department of Family/Community Medicine, University of New Mexico, Albuquerque, New Mexico, USA

, M.D., Ph.D., M.P.H.,

Michael Schatz Department of Allergy-Immunology, Kaiser-Permanente Medical Center, San Diego, California, USA

, M.D., M.S.,

Kenneth Lyons Jones Department of Pediatrics, University of California, San Diego, La Jolla, California, USA

, M.D.,

Carey M. Tucker Midwestern University, Glendale, Arizona, USA

, M.P.H.,

Donald J. Slymen Graduate School of Public Health, San Diego State University, San Diego, California, USA

, Ph.D.,

Hillary S. Klonoff-Cohen Department of Family and Preventive Medicine, University of California, San Diego, La Jolla, California, USA

, Ph.D.,

Louise Gresham Graduate School of Public Health, San Diego State University, San Diego, California, USA

, Ph.D., M.P.H.,

Diana Johnson Department of Pediatrics, University of California, San Diego, La Jolla, California, USA

, M.S.,

Christina D. Chambers Department of Pediatrics, University of California, San Diego, La Jolla, California, USA; Department of Family and Preventive Medicine, University of California, San Diego, La Jolla, California, USA

, Ph.D., M.P.H. &

THE OTIS Collaborative Research Group

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Abstract

Asthma is a prevalent chronic disorder that might substantially complicate pregnancy. Some recent reports suggest that the presence of a female fetus might be associated with worse maternal asthma symptoms during pregnancy. We tested this hypothesis using the sample of 719 pregnant women with asthma prospectively enrolled in the OTIS study. The presence of a female fetus was associated with a higher incidence of hospitalizations for asthma during pregnancy (OR = 1.84; 95% CI: 1.05; 3.21) independent of maternal age, BMI, ethnicity, smoking, and socioeconomic status. The current study suggests that pregnant asthmatic women carrying a girl might be more susceptible to asthma exacerbations.

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Fetal Sex and Maternal Asthma Control in Pregnancy

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Fetal Sex and Maternal Asthma Control in Pregnancy

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