Effect of age on exercise-induced bronchoconstriction in children and adolescents with asthma

Abstract

Objective

The relationship between exercise-induced bronchoconstriction (EIB) and exertional dyspnea in children and adolescents is yet to be fully established. This study examined whether indicators of fractional exhaled nitric oxide (FeNO), forced expiratory volume in 1 s (FEV₁) percent predicted at baseline, and dyspnea are useful for predicting children and adolescents with EIB.

Methods

We enrolled 184 children and adolescents diagnosed with asthma (mean age 11.2 years); participants were divided into two groups according to age (12 years) and were subjected to a 6-min exercise challenge test. Lung function tests and modified Borg scale scores were used to examine perceptions of dyspnea at 0, 5 and 15 min after exercise.

Results

Among children, the maximum percentage drop in FEV₁ after exercise correlated significantly with FeNO (adjusted β = 2.3, P < 0.001) and with the perception of dyspnea at 5 min after exercise (adjusted β = 1.9, P < 0.001). Among adolescents, the maximum percentage drop in FEV₁ correlated with FeNO (adjusted β = 2.7, P = 0.007) and with lung function (FEV₁, percent predicted; adjusted β = −0.28, P = 0.006). Children with EIB had significantly stronger dyspnea after exercise than did children without EIB. Adolescents even without EIB may experience more exertional dyspnea than children without EIB.

Conclusions

Overall, our findings indicated that EIB was associated with FeNO and exertional dyspnea in asthmatic children. By contrast, EIB was associated with FEV₁ percent predicted at baseline and FeNO but not with exertional dyspnea in asthmatic adolescents.

Keywords:

• Diagnostics
• exercise induced
• management/control
• pediatrics
• pathophysiology

Acknowledgements

We are extremely grateful to all the children and parents as well as the managers and nurses who participated in this study.

Declaration of interest

There are no conflicts of interest to declare.