In vitro genotoxicity of extracellular extract from Nostoc piscinale

Eshrat Gharaei-Fathabad Faculty of Pharmacy, Department of Pharmacognosy and Biotechnology, Mazandaran University of Medical Sciences, Sari 48175/861, IranCorrespondence[email protected]

Mojtaba Tabatabaei Yazdi Faculty of Pharmacy, Biotechnology Research Center, Department of Pharmaceutical Biotechnology, Medical Sciences, University of Tehran, Tehran, 14174, Iran

Seyed-Nasser Ostad Faculty of Pharmacy, Medicinal Plant Research Center, Department of Toxicology and Pharmacology, Medical Sciences, University of Tehran, Tehran, 141155, Iran

Mohammad Ali Faramarzi Faculty of Pharmacy, Biotechnology Research Center, Department of Pharmaceutical Biotechnology, Medical Sciences, University of Tehran, Tehran, 14174, Iran

Abstract

The extracellular extract obtained from 3 weeks incubation of the soil isolate cyanobacterium strain Nostoc piscinale GT-319 in BG-11 broth medium showed cytotoxic activity against Chinese Hamster Ovary (CHO) cells. Based on comet assay, a concentration of 333 µg mL⁻¹ (IC₅₀) produced DNA breakages in CHO cells. The concentration of 481 mg kg⁻¹ (LD₅₀) produced acute toxicity in mice at 48 h.

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Acknowledgement

This work was financially supported by a grant from the Medical Sciences/University of Tehran.

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In vitro genotoxicity of extracellular extract from Nostoc piscinale

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In vitro genotoxicity of extracellular extract from Nostoc piscinale

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