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Abstract
The effects of chlorfenapyr nano preparation on mice were examined. The animals were administered with different doses of 4.84, 9.68, or 19.36 mg kg−1 of chlorfenapyr common preparation or nano preparation intraperitoneally (IP). Micronucleus (MN) test and comet assay (CA) experiments revealed that at the same dose, similar DNA damage in the peripheral blood lymphocytes of the mouse and chromosome damage in bone marrow cells of the mouse occurred with chlorfenapyr nano preparation; however, the severity of these effects was less than that found in common preparation. It is noteworthy that there were no differences in apoptotic ratio and live cell percentage in the liver cells of the mouse between these two pesticide formulations using flow cytometry. Data indicate that chlorfenapyr nanoformulation is less toxic to mouse cells than the common formulation.
Acknowledgments
This work was supported by the Natural Science and Technology Development Foundation of Shanghai (no. 053407054) and Agriculture and Science Foundation of Shanghai Jiaotong University (AE150074). We would like to thank Professor Xiuguo Hua and Dr Junfang Zhou for their assistance in experiment.
