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Abstract
The protective effect of Nitraria retusa fruit extract against hepatotoxicity induced by penconazole at a dose of 67 mg/kg body weight given intraperitoneally every two days to male Wistar rats was investigated. Penconazole exposure increased malondialdehyde, hydrogen peroxide, and advanced oxidation protein product levels. Hepatic biomarkers as well as enzymatic (catalase, superoxide dismutase and glutathione peroxidase) and nonenzymatic (vitamin C, non-protein thiols and metallothioneins) antioxidant status were also altered. Treatment with N. retusa extract improved all parameters cited above. Liver histological studies confirmed the biochemical parameters. These results provide a scientific basis for the use of N. retusa fruit against hepatotoxicity.
Acknowledgements
The authors are indebted to Mrs Raoudha Ben Amar Abdennadher and Mr Chedli Tmar for their skillful technical assistance. This work was supported by the Ministry of Higher Education and Scientific Research, Tunisia.
Disclosure statement
No potential conflict of interest was reported by the authors.