Quantitative structure activity-relationships for toxicity screening of pesticide impurities for regulatory submission – practical experiences and challenges

ABSTRACT

The toxicological assessment of impurities of the technical active substance in pesticides with quantitative structure activity-relationship modelling has become an important aspect in authorisation by regulatory bodies. This paper discusses the challenges and drawbacks when predicting toxicities of impurities of technical active substances of pesticides for regulatory submission.

KEYWORDS:

• QSARs
• regulatory submission
• pesticides
• impurities

Acknowledgements

We are grateful to the reviewers for their constructive input.

Disclosure statement

No potential conflict of interest was reported by the authors.

Notes

1. Obtained from five-batch analysis of purity/impurity in samples provided by the manufacturer.