Genotoxicity study of high aspect ratio silver nanowires

ABSTRACT

The genotoxicity potential of silver nanowires synthesized via the solution-based polyol method has been investigated. They were found to be non-mutagenic in three Salmonella strains and were not genotoxic in a clastogenicity assay in mice. Residual surfactant was found to have an effect on the toxicological properties of the nanowires by increasing the rate of Ag⁺ release. Residual surfactant can be easily degraded via a UV treatment.

KEYWORDS:

• Silver nanowires
• mutagenicity
• in vivo chromosomal aberration test
• Ames test

Acknowledgments

Authors are grateful to the Scientific and Technological Research Council of Turkey (TUBITAK) for providing Dr Ashok K Giri, the Senior Visiting Scientist position to work at the Department of Toxicology, Faculty of Pharmacy, Yeditepe University, Istanbul, Turkey.

Disclosure statement

The authors report no conflicts of interest. The authors are solely responsible for the content and writing of the paper.