Effects of aerobic exercise on histopathology and toxicology of ZnO and nano ZnO in male rats

ABSTRACT

The effects of four weeks of aerobic exercise on histopathological and toxicological effects induced by nano ZnO and ZnO powders in male rats were evaluated. Tissue sections of liver and kidneys of ZnO and nano ZnO rats showed some histopathological changes, which were partly reverted by exercise. ZnO and nano ZnO treatments caused an increase in the level of tumor necrosis factor-α, while the mean of Interleukin 10 was declined. Exercise training enhanced the mean value of and declined mean level of in rats treated with ZnO and nano ZnO. The ZnO and ZnO groups demonstrated the highest means of insulin resistance, low density lipoprotein, cholesterol, triglyceride levels and lower mean value of compared to the other groups, while exercise resulted in improvement in mean of these factors.

KEYWORDS:

• ZnO
• nano ZnO
• aerobic exercise
• liver and kidney function
• inflammation

Acknowledgments

The authors wish to extend their appreciation to the staff at the Department of Exercise Physiology, Faculty of Humanities, Sari Branch, Islamic Azad University, Sari-Iran.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported by a grant provided from the Exercise Physiology, Faculty of Humanities, Sari Branch, Islamic Azad University, Sari-Iran. Grant number [Number: 91-1-25].