http://orcid.org/0000-0003-2434-4791
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Abstract
The impact of sub-lethal exposure to deltamethrin on the expression of hepcidin, ferroportin and transferrin genes in Wistar rats was studied. A dosage of 30 mg/kg per day for five days was found to modify the hepcidin-ferroportin axis that primarily governs iron homeostasis. Significant variations in erythrocyte, leukocyte, lymphocyte, platelet and monocyte counts, as well as the reduced serum protein profile, suggested anemia. The results collectively demonstrated the novel finding of deltamethrin’s disruptive effect on iron homeostasis.
Disclosure statement
No potential conflict of interest was reported by the authors.
Additional information
Funding
This research was undertaken with the financial support of Higher Education Commission (HEC), Pakistan, under the Interim Placement of Fresh PhDs (IPFP) program [21-411 SRGP/R&D/HEC/2014].