Protective effects of (-)-epigallocatechin gallate and curcumin against acrylamide toxicity

Abstract

Human lymphocytes as well as zebrafish embryos were used to study the toxicity of acrylamide, and the intervention effects of the dietary antioxidants (-)-epigallocatechin gallate and curcumin have been examined. The alkaline comet assay revealed that acrylamide (1, 5, 10 mmol/L) had dose-response effects on basic DNA damage and oxidative DNA damage in human lymphocytes. Exposure of zebrafish embryos to acrylamide resulted in decrease of hatching rate, and in increases of mortality and teratogenicity. (-)-Epigallocatechin gallate and curcumin reduced DNA damage and protected zebrafish embryos in the growth and development.

Keywords:

• Acrylamide
• genotoxicity
• developmental toxicity
• (-)- epigallocatechin gallate
• curcumin
• human lymphocytes
• zebrafish embryos

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This work was supported by Funds of Joint Plan for Health Education in Fujian [#WKJ2016-2-25], and Project in Fuzhou Science and Technology Bureau [#2018-G-49], and National Natural Science Foundation of China [#81971837].