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Abstract
Oral administration of metanil yellow (MY) at 3.0% (w/w) dose level to adult male albino rats maintained on normal protein (NP) and low protein (LP) diet for 30 days resulted in a remarkable decrease in food intake and body weight gain in both NP and LP groups. The activities of lactate dehydrogenase, aspartate and alanine transferases and alkaline phosphatase increased significantly in the serum of animals receiving LP and LP + MY diets, whereas their levels in liver decreased. Lactic acid content was unaffected in serum but decreased significantly in liver at LP and LP + MY levels. The extent of increase in serum or decrease in liver of various parameters was more in malnourished animals receiving metanil yellow than in malnourished control (LP) animals. The results suggest liver damage in protein deficient animals with and without metanil yellow exposure; the damage being more pronounced in case of LP + MY group. The above parameters were almost unchanged in NP and NP + MY groups of animals. These findings indicate that the protein deficiency make the animals more vulnerable and it is an important predisposing factor in the hepatic toxicity of metanil yellow.