Evaluation of mutagenicity of complex mixture of nitroarenes using mouse micronuclei test

Abstract

A mixture of five nitroarenes, 3‐nitrofluoranthene, 2‐nitrofluorene, 2,7‐dinitrofluorene, 2,7‐dinitro‐9‐fluorenone and 9‐nitroanthracene, was administered to ddY male mice by intraperitoneal injection. At 48 h after treatment with the mixture, the frequency of micronucleated reticulocytes increased significantly (p < 0.01), and was 0.55, 0.60, 0.85 and 0.77%, at 50, 100, 200 and 400 mg/kg, respectively. However, the frequency of micronucleated reticulocytes did not increase over control values after intraperitoneal administration of each nitroarene alone at 80 mg/kg.

Key Words:

• 3‐nitrofluoranthene
• 2‐nitrofluorene
• 2,7‐dinitrofluorene
• 2,7‐dinitro‐9‐fluorenone and 9‐nitroanthracene
• micronuclei test

Notes

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