Hydroxyl radical generation during oxidation of catecholamines and dopaFootnote*
This paper was supported by the KBN project No. 108/E‐364/BW/96

M. Bounias Biomathématique et toxicologie, University of d'Avignon, Avignon, F 84000, France; The Alexandria Institute, New York, USA

J. Køl Adny Clinic of General and Vascular Surgery, Pomeranian Medical Academy, Powstańców Wielkopolskich 72, Szczecin, 70–111, Poland

I. Kruk Institute of Physics, Technical University of Szczecin, Al. Piastôw 48/49, Szczecin, 70–310, Poland

T. Michalska Institute of Physics, Technical University of Szczecin, Al. Piastôw 48/49, Szczecin, 70–310, Poland

Abstract

Catecholamines (adrenaline, noradrenaline, dopamine, isoprotenerol) and DOPA greatly accelerate the generation of hydroxyl radicals from H₂O₂ in the presence of Fe‐ions as studied by the deoxyribose assay.

Hydroxyl radical scavengers (formate, methanol, mannitol, cysteine, glutathione, histidine) and catalase inhibited the degradation of deoxyribose confirming that HO‐radicals are responsible for the degradation of the sugar.

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This paper was supported by the KBN project No. 108/E‐364/BW/96

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Hydroxyl radical generation during oxidation of catecholamines and dopaFootnote*
This paper was supported by the KBN project No. 108/E‐364/BW/96

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Hydroxyl radical generation during oxidation of catecholamines and dopaFootnote*This paper was supported by the KBN project No. 108/E‐364/BW/96

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Hydroxyl radical generation during oxidation of catecholamines and dopaFootnote*
This paper was supported by the KBN project No. 108/E‐364/BW/96