Synthesis of aliphatic thiomorpholides by willgerodt-kindler reaction under solvent-free conditions

The Willgerodt-Kindler reaction of aliphatic ketones and aldehydes with sulfur and morpholine under solvent-free conditions was performed in a domestic microwave oven. The method is simple, rapid and avoids prolonged heating with solvents.

Keywords:

• Aliphatic Thiomorpholides
• Willgerodt-Kindler Reaction
• Microwave Activation
• Solvent-free Condition