Alignment of Magnetite-Loaded High Aspect Ratio Aerosol Drug Particles with Magnetic Fields

Abstract

The present note demonstrates magnetic field alignment of high aspect ratio pharmaceutical aerosol particles loaded with magnetite nanoparticles. This alignment is used to reduce the penetration of the particles through polycarbonate membrane filters when a magnetic field is generated parallel to the face of the membrane. Possible application of magnetic field alignment to noninvasively target respiratory tract deposition during aerosol drug delivery is discussed.

Acknowledgments

The authors acknowledge funding from the Natural Sciences and Engineering Research Council of Canada, the Alberta Ingenuity Fund, and the Killam Fund. The authors also thank Dr. Ming Chen for the electron microscope imaging used in this study.