Abstract
Background
Antibiotic resistance is an increasing global threat, accelerated by both misuse and overuse of antibiotics. Most antibiotics to humans are prescribed in primary care, commonly for respiratory symptoms, and there is a need for research on the usage of and outcomes after antibiotic treatment to counteract antibiotic resistance.
Objective
To evaluate symptom duration, treatment length, and adverse events of antibiotic treatment in children.
Design and Setting
Observational study at four out-of-hours services and one paediatric emergency clinic in Norwegian emergency primary care.
Subjects
266 children aged 0 to 6 years with fever or respiratory symptoms.
Main Outcome Measures
Duration of symptoms and absenteeism from kindergarten/school, treatment length, and reported adverse events.
Results
There were no differences in duration of symptoms, fever or absenteeism when comparing the groups prescribed (30.8%) and not prescribed (69.2%) antibiotics. This lack of difference remained when analysing the subgroup with otitis media.
In the group prescribed antibiotics, 84.5% of parents reported giving antibiotics for 5-7 days, and 50.7% reported no difficulties. Adverse events of antibiotics were reported in 42.3% of the cases, the vast majority being gastrointestinal disturbances.
Conclusion
Children with fever or respiratory symptoms experience similar duration of symptoms and absenteeism regardless of antibiotic treatment. A substantial number of parents reported adverse events when the child received antibiotics. Several parents experienced additional difficulties with the treatment, some ending treatment within day 4.
Trial Registration Number
NCT02496559; Results.
Key Points
Children with fever or respiratory symptoms treated at OOH services experience similar duration of symptoms or absenteeism, regardless of antibiotic treatment.
Parents often choose to end antibiotic treatment prematurely due to adverse events, bad taste, or that they find treatment unnecessary.
Children often experience adverse events when prescribed antibiotics, mainly gastrointestinal symptoms.
Acknowledgements
The authors thank the children, parents, and OOH services at Sotra, Askøy, Nordhordaland, Os and the Paediatric Emergency Clinic at Haukeland University Hospital, who participated in the study.
Ethical approval
The study has been approved by the Regional Committee for Medical and Health Research Ethics (2012/1471/REK Vest).
Disclosure statement
This research received no specific funding.
Additional files
Questionnaire 1 (in Norwegian): Spørjeskjema til foreldre på legevakt.
Questionnaire 2 (in Norwegian): Spørjeskjema etter 7 dager.
Data availability statement
The data underlying this article will be shared on reasonable request to the corresponding author.