101
Views
0
CrossRef citations to date
0
Altmetric
Original Article

Changes in Renal Dimensions Evaluated by Magnetic Resonance Imaging and Ultrasonography During Long-term Ciclosporin-A Treatment

, , , , , , , & show all
Pages 58-64 | Accepted 17 Sep 2005, Published online: 09 Jul 2009
 

Abstract

Purpose: To investigate changes in renal dimensions during long-term treatment with ciclosporin-A (CsA).

Material and Methods: Five mini-Göttingen pigs were treated with CsA (10 mg kg−1day−1) for 6 months; 3 untreated animals served as controls. Renal length was measured by magnetic resonance imaging (MRI) and ultrasonography (US); renal volume by MRI. Examinations were performed at baseline (0 weeks) and after the start of CsA treatment at intervals of 5 weeks (5–25 weeks).

Results: Comparison of baseline and end-point data (0 weeks vs. 25 weeks) revealed a statistically significant increase in renal volume in CsA-treated animals (87.1 cm3 vs. 55.9 cm3, P = 0.002). Renal volume remained unchanged in the control group. A significant increase in renal length was found both in the CsA-treated pigs (MRI: 96 mm vs. 84 mm, P<0.001; US: 94 mm vs. 81 mm, P<0.001) and in the control group (MRI: 97 mm vs. 85 mm, P<0.001; US: 89 mm vs. 81 mm, P = 0.018). No difference was found between MRI and US measurements based on 40 paired units (MRI variance: 2.4–30.3% and US variance: −5.1–40.6%, P = 0.133).

Conclusion: During long-term CsA treatment, renal volume increases in mini-pigs, but there is no correlation between the increase in volume and the increase in length in this pig model.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.