Antiemetic Effects of Lerisetron in Radiation-induced Emesis in the Dog

Ignacio A. Gomez-de-Segura From the Departments of Experimental Surgery (I.A. Gomez-de-Segura, E. De Miguel) and Oncology Radiotherapy (A.G. Grande), La Paz Hospital, Madrid, Spain

Antonio G. Grande From the Departments of Experimental Surgery (I.A. Gomez-de-Segura, E. De Miguel) and Oncology Radiotherapy (A.G. Grande), La Paz Hospital, Madrid, Spain

Enrique De Miguel From the Departments of Experimental Surgery (I.A. Gomez-de-Segura, E. De Miguel) and Oncology Radiotherapy (A.G. Grande), La Paz Hospital, Madrid, Spain

Abstract

The 5-HT3 receptor antagonists are the most potent antiemetics known at present. Lerisetron is a new 5-HT3 receptor antagonist chemically unrelated to other antagonists like Ondansetron. An emesis model in the dog induced by irradiation with ⁶⁰Co was used, and 8 Gy were administered over the total body surface. An irradiated control group was established and received no medication, and two irradiated groups received treatment with either Ondansetron or Lerisetron. The 'up-down' technique was employed to determine the effective dose (ED⁵⁰

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Antiemetic Effects of Lerisetron in Radiation-induced Emesis in the Dog

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Antiemetic Effects of Lerisetron in Radiation-induced Emesis in the Dog

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