Differences between patient and physician opinions on adherence to medication for hypertension and diabetes mellitus

Abstract

Background: Non-adherence to prescribed medication presents a barrier to effective treatment. In order to find improved ways of tackling non-adherence, it is important to understand the perspective of both patients and physicians.

Method: A web-based survey study was performed to obtain the views and opinions of patients receiving medical treatment for hypertension or diabetes mellitus in Japan, and physicians treating such patients, on adherence to medication.

Results: Forty-four percent of both physicians and patients placed great importance on medication adherence, but 11% of patients considered it of low importance. Overall, 85% of patients reported taking their medication correctly. Patients missed a mean of 4.8 or 5.4 daily doses per 30 day prescription based on patient and physician estimates, respectively. Both patients (64%) and physicians (23%) considered the main reason patients forgot to take their medication was that they “inadvertently forgot”. Only 1% of physicians said they do not specifically check for residual drugs, but 46% of patients said they do not report missed doses to their doctor. Measures taken by physicians to reduce residual drugs included use of single packs (64%) and reductions in administration frequency (55%); 63% adjusted prescriptions to take account of any remaining drugs. Only 4% of physicians were satisfied with the effectiveness of measures to reduce non-adherence, whereas 59% of patients felt they managed to successfully perform measures to avoid forgetting to take drugs.

Limitation: The study questionnaires were newly developed and did not incorporate validated instruments to assess adherence.

Conclusion: Similar proportions of physicians and patients consider medication adherence to be important, but their opinions about measures used to improve adherence differ to some extent. Importantly, almost half of patients do not tell their doctor about missed doses.

Keywords:

• Diabetes mellitus
• Hypertension
• Medication adherence
• Medication compliance
• Patient
• Physician

Transparency

Declaration of funding

This study was funded by Takeda Pharmaceutical Company Limited.

Declaration of financial/other relationships

Y.L., K.M., and M.H. have disclosed that they are employees of Takeda Pharmaceutical Company Limited.

CMRO peer reviewers on this manuscript have received an honorarium from CMRO for their review work, but have no relevant financial or other relationships to disclose.

Acknowledgments

The authors thank Content Ed Net (Japan) for editorial support funded by Takeda Pharmaceutical Company Limited and Macromill Carenet Inc. for performing the web-based survey.