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Abstract
Objective: To estimate the cost-effectiveness of using an extensively hydrolyzed casein formula containing the probiotic Lactobacillus rhamnosus GG (eHCF + LGG; Nutramigen LGG) compared with an eHCF alone and an amino acid formula (AAF) in treating cow’s milk allergy (CMA) in the US, from the perspective of third-party insurers and from parents.
Methods: A decision model was used to estimate the probability of cow’s milk allergic infants developing tolerance to cow’s milk by 18 months. The model also estimated the cost to insurers and parents (US dollars at 2016 prices) of managing infants over 18 months after starting one of the formulae, as well as the relative cost-effectiveness of each of the formulae.
Results: The probability of developing tolerance to cow’s milk was higher among infants who were fed eHCF + LGG compared with those fed an eHCF alone or an AAF. Infants who are initially fed with eHCF + LGG are expected to utilize fewer healthcare resources than those fed with one of the other formulae. Hence, the estimated total healthcare cost incurred by third-party insurers and parents of initially feeding infants with eHCF + LGG was less than that of feeding infants with an eHCF alone or an AAF.
Conclusion: Initial management of newly-diagnosed cow's milk allergic infants with eHCF + LGG was found to afford a cost-effective strategy to both third-party insurers and parents when compared to an eHCF alone or an AAF.
Acknowledgments
Mead Johnson Nutrition had no influence on (1) the study design, (2) the collection, analysis, and interpretation of data; (3) the writing of the manuscript; or (4) the decision to submit the manuscript for publication. The views expressed in this article are those of the authors, and not necessarily those of Mead Johnson Nutrition. The authors also wish to thank the following general pediatricians for their contributions to this study: Dr Carla Bloedel, Albuquerque, NM; Dr Brandon Davison-Tracy, Denver, CO; Dr Mark DiDea, Orlando, FL; Dr Alex Gomez, Pediatric Associates, Trinity, FL; Dr Robert McGahey, Detroit, MI; and Dr Jay Weissbrot, White Plains, NY. The authors also wish to thank the following paediatric specialists for their contributions to this study: Dr Majdi Abu-Salih, gastroenterologist, Indianapolis, IN; Dr Donald George, gastroenterologist, Jacksonville, FL; Dr Sharad Kunnath, gastroenterologist, Boys Town NE.