Transparency
Declaration of funding
Acaster Lloyd Consulting Ltd and Oxford PharmaGenesis received funding from Novartis Pharma AG.
Author contributions:
A.L., H.S. and N.A. drafted the manuscript, critically reviewed all versions and approved the final version.
Declaration of financial/other relationships
A.L. has disclosed that he is an employee of Acaster Lloyd Consulting Ltd, London, UK. H.S. has disclosed that she is a paid employee of Oxford PharmaGenesis, Oxford, UK. N.A. has disclosed that he is a paid employee of Novartis Pharma AG, Basel, Switzerland. CMRO peer reviewers on this manuscript have received an honorarium from CMRO for their review work but have no relevant financial or other relationships to disclose.
Acknowledgements
The authors thank John Findlay at Oxford PharmaGenesis, Oxford, UK for medical writing support.