Graves’ disease could increase polycystic ovary syndrome and comorbidities in Taiwan

Abstract

Background

To investigate the association between Graves’ disease (GD) and polycystic ovary syndrome (PCOS) and its comorbidities.

Methods

Logistic regression was performed to determine the association between the two conditions. Cumulative incidence curves were obtained using the Kaplan–Meier method and log-rank test. Hazard ratios were determined using the Cox proportional hazards regression model.

Results

We included 5399 patients with GD as the study group and 10,798 patients without GD as the control group. The cumulative incidence curve of PCOS in patients with GD was significantly higher than that in patients without GD (p = .02). The adjusted hazard ratio for PCOS in patients with GD compared with patients without GD was 1.47 (95%CI = 1.09–1.98). The adjusted odds ratio of hyperlipidemia in patients with GD and PCOS was 2.18 (95%CI = 1.14–4.17) higher than that in patients with GD only.

Conclusion

Our study demonstrated that women with GD could be at risk of developing PCOS; additionally, a higher incidence of comorbidities, including hyperlipidemia, was noted in women with GD and PCOS.

Keywords:

• Graves’ disease (GD)
• polycystic ovary syndrome (PCOS)
• hyperlipidemia

Transparency

Declaration of funding

This study is supported in part by Taiwan Ministry of Health and Welfare Clinical Trial and Research Center of Excellence [MOHW108-TDU-B-212-133004]; China Medical University Hospital [DMR-107-192, CMU107-ASIA-19]; Academia Sinica Stroke Biosignature Project [BM10701010021]; MOST Clinical Trial Consortium for Stroke [MOST 108-2321-B-039-003-]; Tseng-Lien Lin Foundation, Taichung, Taiwan; and Katsuzo and Kiyo Aoshima Memorial Funds, Japan. The funders had no role in the study design, data collection and analysis, the decision to publish, or preparation of the manuscript. No additional external funding was received for this study

Declaration of financial/other relationships

All authors report no conflicts of interest. Peer reviewers on this manuscript have no relevant financial or other relationships to disclose.

Author contributions

All authors have contributed significantly, and that all authors are in agreement with the content of the manuscript: conception/design: H-HC, C-HK; provision of study materials: C-HK; collection and/or assembly of data: all authors; data analysis and interpretation: all authors; manuscript writing: all authors; final approval of manuscript: all authors.

Acknowledgements

None reported.