![Sample our Bioscience journals, sign in here to start your access, Latest two full volumes FREE to you for 14 days]({"type":"image" , "src" : "/sda/5925/TOC-Subject-Sample-2021-Bioscience.jpg"})
Abstract
Background
Cloninger’s psychobiosocial model of personality proposes that consistent patterns of health behavior are determined by the complex interaction of different neurobiological processes of the patient’s temperament and character dimensions. Poor medication adherence is a pervasive problem among glaucoma patients and can lead to increased morbidity and disability. The objective of the present study was to investigate the association between Cloninger’s personality dimensions and medication adherence among glaucoma patients.
Methods
The cross-sectional study was conducted among 113 primary open-angle glaucoma (POAG) patients. The treatment adherence was assessed through a valid and reliable self-administered questionnaire, the Culig Adherence Scale (CAS). Personality dimensions were evaluated using the abbreviated version of the Temperament and Character Inventory-Revised (TCI-140). Statistical analyses were performed using TIBCO Statistica 14.0.1. The study protocol was registered in the DRKS – German Clinical Trials Register; (DRKS-ID: DRKS00022081).
Results
According to CAS, only 39.8% of patients were adherent to glaucoma treatment. Adherence was significantly negatively related only to the character dimension of Self-Transcendence (p < 0.05). No other TCI-140 dimension was significantly associated with medication adherence (p > 0.05).
Conclusions
The results suggest that POAG patients with higher scores on the Self-Transcendent personality dimension are more likely to experience difficulties adhering to medication regimen. The study highlights the importance of a holistic approach to glaucoma treatment, which takes into account not only the biological aspects of disease but also the psychosocial factors that influence patient behavior. Healthcare providers may need to consider glaucoma patients’ personality dimensions, beliefs and values when developing treatment plans and strategies to improve medication adherence.
Transparency
Declaration of financial/other relationships
The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties. Peer reviewers on this manuscript have no relevant financial or other relationships to disclose.
Author contributions
Dina Lešin Gaćina, Darko Marčinko, and Sonja Jandroković conceived the concept of the study and contributed to the design of the research. Tomislav Kuzman, Ivan Škegro, Sania Vidas Pauk, Bernarda Škegro, Martina Tomić, and Tomislav Bulum were involved in clinical work and data collection. All authors of the study analyzed, discussed and interpreted results and search the literature. Dina Lešin Gaćina, Sonja Jandroković, and Martina Tomić drafted the manuscript. Dina Lešin Gaćina, Sonja Jandroković, and Bernarda Škegro completed statistical analyses. All authors edited and approved the final version of the manuscript critically for important intellectual content.
Acknowledgements
None.
Data availability statement
The data presented in this study are available on request from the corresponding author.
Ethics statement
The study protocol was approved by the institutional ethics committee (class 8.1-20/65, reference number 2/02/21 AG). All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.”