Inhibition of Molar Eruption and Root Elongation in MT1-MMP-Deficient Mice

W. Beertsen Department of Periodontology, Academic Center for Dentistry Amsterdam, University of Amsterdam, and Department of Cell Biology and Histology, Academic Medical Center, Amsterdam, The Netherlands

K. Holmbeck National Institute of Dental and Craniofacial Research (NIDCR), Bethesda, Maryland, USA

A. Niehof Department of Periodontology, Academic Center for Dentistry Amsterdam, University of Amsterdam, and Department of Cell Biology and Histology, Academic Medical Center, Amsterdam, The Netherlands

P. Bianco National Institute of Dental and Craniofacial Research (NIDCR), Bethesda, Maryland, USA

K. Chrysovergis National Institute of Dental and Craniofacial Research (NIDCR), Bethesda, Maryland, USA

H. Birkedal-Hansen National Institute of Dental and Craniofacial Research (NIDCR), Bethesda, Maryland, USA

V. Everts Department of Periodontology, Academic Center for Dentistry Amsterdam, University of Amsterdam, and Department of Cell Biology and Histology, Academic Medical Center, Amsterdam, The Netherlands

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Abstract

To study whether eruption of teeth and root growth require remodeling of collagen in the peridental tissues, we studied molar development in mice deficient in MT1-MMP, an enzyme essential for remodeling of soft tissue-hard tissue interfaces. The lower jaws of deficient mice and their wildtype littermates were subjected to stereologic analysis. It was shown that in deficient animals, eruption and root elongation were severely inhibited, signifying a role of the enzyme in these developmental processes.

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Inhibition of Molar Eruption and Root Elongation in MT1-MMP-Deficient Mice

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Inhibition of Molar Eruption and Root Elongation in MT1-MMP-Deficient Mice

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