Tissue-Specific shRNA Delivery: A Novel Approach for Gene Therapy in Cancer

Shilenath Ghatak Department of Cell Biology and Anatomy, MUSC, Charleston, South Carolina, USA

Viacent C. Hascall Department of Biomedical Engineering/ND20, Cleveland Clinic, Cleveland, Ohio, USA

Franklin G. Berger Department of Biological Sciences, USC at Columbia, Columbia, South Carolina, USA

Maria M. O. Penas Department of Biological Sciences, USC at Columbia, Columbia, South Carolina, USA

Celestia Davis Department of Biological Sciences, USC at Columbia, Columbia, South Carolina, USA

Esmaiel Jabari Department of Chemical Engineering, USC at Columbia, South Carolina, USA

Xuezhong He Department of Chemical Engineering, USC at Columbia, South Carolina, USA

James S. Norris Department of Microbiology and Immunology, MUSC, Charleston, South Carolina, USA

Yujing Dang Department of Cell Biology and Anatomy, MUSC, Charleston, South Carolina, USA

Roger R. Markwald Department of Cell Biology and Anatomy, MUSC, Charleston, South Carolina, USA

Suniti Misra Department of Cell Biology and Anatomy, MUSC, Charleston, South Carolina, USA

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Abstract

A novel tissue-specific shRNA delivery system has been developed using cre-lox technology. Conditionally silenced pSico vector containing oligonucleotides of CD44shRNA and tissue-specific promoter-driven Cre-recombinase expression vector are packaged into transferrin-coated nanoparticles that can deliver shRNA into specific tumors. This system has strong potential in cancer therapy.

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Tissue-Specific shRNA Delivery: A Novel Approach for Gene Therapy in Cancer

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Tissue-Specific shRNA Delivery: A Novel Approach for Gene Therapy in Cancer

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