CD14 and TNFα promoter polymorphisms in patients with acute arthritis

Heikki Repo Department of Medicine, Division of Infectious Diseases, Helsinki University Central Hospital, 2Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki, 3Department of Clinical Chemistry, Laboratory Diagnostics, and 4Department of Medical Genetics, Laboratory Diagnostics, Helsinki University Central Hospital, 5Department of Pathology and Laboratory Medicine, UCLA, Los Angeles, CA, 6Division of Hematology-Oncology, Weill Medical College of Cornell University, New York, NY, 7Department of Medicine, Division of Rheumatology, Helsinki University Central Hospital, Finland

Krista Anttonen Department of Medicine, Division of Infectious Diseases, Helsinki University Central Hospital, 2Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki, 3Department of Clinical Chemistry, Laboratory Diagnostics, and 4Department of Medical Genetics, Laboratory Diagnostics, Helsinki University Central Hospital, 5Department of Pathology and Laboratory Medicine, UCLA, Los Angeles, CA, 6Division of Hematology-Oncology, Weill Medical College of Cornell University, New York, NY, 7Department of Medicine, Division of Rheumatology, Helsinki University Central Hospital, Finland

Sami K. Kilpinen Department of Medicine, Division of Infectious Diseases, Helsinki University Central Hospital, 2Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki, 3Department of Clinical Chemistry, Laboratory Diagnostics, and 4Department of Medical Genetics, Laboratory Diagnostics, Helsinki University Central Hospital, 5Department of Pathology and Laboratory Medicine, UCLA, Los Angeles, CA, 6Division of Hematology-Oncology, Weill Medical College of Cornell University, New York, NY, 7Department of Medicine, Division of Rheumatology, Helsinki University Central Hospital, Finland

Aarno Palotie Department of Medicine, Division of Infectious Diseases, Helsinki University Central Hospital, 2Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki, 3Department of Clinical Chemistry, Laboratory Diagnostics, and 4Department of Medical Genetics, Laboratory Diagnostics, Helsinki University Central Hospital, 5Department of Pathology and Laboratory Medicine, UCLA, Los Angeles, CA, 6Division of Hematology-Oncology, Weill Medical College of Cornell University, New York, NY, 7Department of Medicine, Division of Rheumatology, Helsinki University Central Hospital, Finland

Petri Salven Department of Medicine, Division of Infectious Diseases, Helsinki University Central Hospital, 2Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki, 3Department of Clinical Chemistry, Laboratory Diagnostics, and 4Department of Medical Genetics, Laboratory Diagnostics, Helsinki University Central Hospital, 5Department of Pathology and Laboratory Medicine, UCLA, Los Angeles, CA, 6Division of Hematology-Oncology, Weill Medical College of Cornell University, New York, NY, 7Department of Medicine, Division of Rheumatology, Helsinki University Central Hospital, Finland

Arto Orpana Department of Medicine, Division of Infectious Diseases, Helsinki University Central Hospital, 2Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki, 3Department of Clinical Chemistry, Laboratory Diagnostics, and 4Department of Medical Genetics, Laboratory Diagnostics, Helsinki University Central Hospital, 5Department of Pathology and Laboratory Medicine, UCLA, Los Angeles, CA, 6Division of Hematology-Oncology, Weill Medical College of Cornell University, New York, NY, 7Department of Medicine, Division of Rheumatology, Helsinki University Central Hospital, Finland

Marjatta Leirisalo-Repo Department of Medicine, Division of Infectious Diseases, Helsinki University Central Hospital, 2Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki, 3Department of Clinical Chemistry, Laboratory Diagnostics, and 4Department of Medical Genetics, Laboratory Diagnostics, Helsinki University Central Hospital, 5Department of Pathology and Laboratory Medicine, UCLA, Los Angeles, CA, 6Division of Hematology-Oncology, Weill Medical College of Cornell University, New York, NY, 7Department of Medicine, Division of Rheumatology, Helsinki University Central Hospital, Finland

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Abstract

Objective. To examine CD14 and TNF &#102 gene polymorphisms in early arthritis in relation to clinical outcome. Methods. We studied 141 Caucasians who had had early arthritis 10 to 38 years earlier. We analysed CD14 (-159) and TNF &#102 (- 238, - 308, - 376) polymorphisms using a novel cycle minisequencing method. DNA pools from 370 Caucasian blood donors served as controls. Results. CD14 (-159)C &#77 T allele frequencies were comparable among patients and controls (39% vs 40%). Fifty men and 42 women had recovered while 24 men and six women had chronic spondyloarthropathy (SpA). Mutant T allele frequency was higher in the chronic SpA group than in the recovered group in women (75% vs 32%, relative risk 1.3, 95% confidence limit 1.1 to 1.6, P= 0.011), but not in men (38% vs 44%). All female patients with chronic SpA had CD14 (- 159)T allele and none had a possibly protective TNF &#102 (- 308)G &#77 A allele. Conclusion. Possession of CD14 (- 159)T allele does not increase risk of ReA but may increase susceptibility of female patients to development of chronic SpA.

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CD14 and TNFα promoter polymorphisms in patients with acute arthritis

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CD14 and TNFα promoter polymorphisms in patients with acute arthritis

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