Functional polymorphisms in matrix metalloproteinase‐1 and monocyte chemoattractant protein‐1 and rheumatoid arthritis

Abstract

The aim of this study is to investigate whether the functional polymorphisms in the promoter of matrix metalloproteinase‐1 (MMP‐1) and in the regulatory region of the monocyte chemoattractant protein‐1 (MCP‐1) gene are associated with susceptibility to rheumatoid arthritis (RA) and its clinical features. The MMP‐1 1G/2G polymorphism and the MCP‐1 promoter A/G polymorphism were determined by polymerase chain reaction‐restriction fragment length polymorphism in 117 RA patients and 97 healthy controls. The genotype distribution of the MMP‐1 promoter did not differ between RA patients and control subjects. However, in the 2G/2G genotype, ESR and Plat were higher than the 1G/1G genotype. The genotype distribution of the MCP‐1 promoter did not differ between the RA and control groups. Clinically there was no significant difference among RA patients according to the MCP‐1 promoter genotypes. Our data show that the functional promoter polymorphism in the MMP‐1 promoter may not play an important role in the susceptibility of RA, but the polymorphism may be related to clinical phenotypes.

• matrix metalloproteinase‐1
• monocyte chemoattractant protein‐1 polymorphisms
• rheumatoid arthritis