Liver infarction in a woman with systemic lupus erythematosus and secondary anti‐phospholipid and HELLP syndrome

Abstract

We report a 39‐year‐old primigravida, a case of systemic lupus erythematosus (SLE) and secondary anti‐phospholipid syndrome (APS) with a smooth antenatal course who delivered by caesarean for non‐reassuring foetal heart rate. On day 2 postoperatively, she developed a sudden severe colicky upper abdominal pain with tachypnoea, dyspnoea, and tachycardia, and blood pressure (BP) reaching 150/95 mmHg. Computed tomography of the abdomen revealed lesions consistent with liver infarction. She developed haemolytic anaemia, elevated liver enzymes, and low platelets (HELLP syndrome); heparin and methylprednisolone were started. On day 3, BP normalized, respiratory symptoms improved but abdominal symptoms persisted. Methylprednisolone was increased to 80 mg/day on day 8 when she had significant clinical response and was discharged on day 16. This case emphasizes that a morbid clinical course including liver infarction should be anticipated in patients with SLE and APS complicated with HELLP syndrome.