Analytical model of graphene-based biosensors for bacteria detection

Abstract

In this research, a set of novel models based on field effect transistor (FET) structure using graphene have been proposed with the current–voltage (I–V) characteristics of graphene employed to model the sensing mechanism. It has been observed that the graphene device experiences a drastic increase in conductance when exposed to Escherichia coli bacteria at 0– cfu/mL concentrations. Hence, simplicity of the structure, fast response rate and high sensitivity of this nanoelectronic biosensor make it a more suitable device in screening and functional studies of antibacterial drugs and an ideal high-throughput platform that can detect any pathogenic bacteria. Accordingly, the proposed model exhibits a satisfactory agreement with the experimental data.

Keywords:

• graphene
• E. coli bacteria
• biosensor
• field effect transistor
• I–V characteristics

Additional information

Funding

The authors would like to thank the Ministry of Higher Education (MOHE), Malaysia [grant number 4F382], and the Universiti Teknologi Malaysia [grant number 03H86], [grant number 04H40] for the financial support received during the investigation.