187
Views
5
CrossRef citations to date
0
Altmetric
Original Articles

Blood transfusion impact on levels of some phthalate esters in blood, urine and breast milk of some nursing mothers in Ibadan South-Western Nigeria

, , , , &
Pages 702-718 | Received 08 Jul 2019, Accepted 18 Sep 2019, Published online: 04 Oct 2019
 

ABSTRACT

Studies had suggested possible association between polymer products and phthalate esters exposures in humans, but only a few had studied the level of phthalates that leaches out of these polymers into blood, which would eventually be detectable in urine or breast milk samples of blood transfusion recipients. This study examined the level of diethyl phthalate (DEP), dipropyl phthalate (DPP), di-n-butyl phthalate (DnBP), diethylhexyl phthalate (DEHP), monoethyl phthalate (MEP), monopropyl phthalate (MPP), monobutyl phthalate (MBP), mono-2-ethylhexyl phthalate (MEHP), mono-2-ethyl-5-hydroxyhexyl phthalate (MEHHP) and mono-2-ethyl-5-oxohexyl phthalate (MEOHP) using liquid chromatography tandem mass spectrometry in blood, urine and breast milk samples of mothers who had blood transfusion during intra-partum care. We also examined the level of phthalates in some controls who were mothers who had no transfusion at all during intra-partum care. The transfused mothers had significantly high levels of MEHHP, MEHP, MPP and DEHP in all of their samples and high DBP and MEP in almost all of the samples. Other phthalates were also detected at high concentrations, although relatively low levels of these were detected in all of the control samples. Analysis of variance (ANOVA) showed significant difference between the samples and controls. In this study, a positive association between blood transfusion and phthalate exposure in transfused mothers was established.

Acknowledgments

The authors gratefully acknowledge the TWAS, CSIR India and Indian Institute of Integrative Medicine Jammu-Tawi, India and Dr. R.K. Khajuria, for the fellowship granted to Mr. O.J. Onipede. The HOD of the Department of Chemistry, University of Ibadan, Ibadan, Nigeria is appreciated for providing conducive environment for this research. We also gratefully acknowledge all participants recruited for this study.

Disclosure statement

No potential conflict of interest was reported by the authors.

Correction Statement

This article has been republished with minor changes. These changes do not impact the academic content of the article.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.