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Original Articles

Susceptibility of different strains of pigeon herpesvirus to trisodium phosphonoformate

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Pages 23-29 | Received 21 Apr 1980, Accepted 31 Jul 1980, Published online: 12 Nov 2007
 

Summary

The susceptibility to trisodium phosphonoformate of five strains of pigeon herpesvirus (Pigeon Herpesvirus 1, PHV) was compared by measuring the mean plaque size variations in the presence of different concentrations of the compound.

Significant differences in their susceptibility to phosphonoformate were observed, but none of them was found to be naturally resistant. This finding may be of significance for a possible clinical application in the treatment of pigeon herpesvirus infection.

Resume

La sensibilité au phosphonoformate de sodium de cinq souches de virus herpès du pigeon (Pigeon Herpesvirus 1, PHV) a été étudiée en comparant les variations de la surface des plages liées aux différentes concentrations du produit.

Les cinq souches montrent des sensibilités différentes au phosphonoformate, mais aucune d'entre elles n'y est naturellement résistante. Ces résultats sont encourageants pour une utilisation clinique du phosphonoformate dans le traitement de l'infection herpétique du pigeon.

Zusammenfassung

Die Empfindlichkeit von fünf Stämmen des Taubenherpesvirus (Taubenherpesvirus 1, PHV) gegen Trinatriumphosphonoformat wurde durch Messungen der Größenvariation‐en der Plaques in Gegenwart verschiedener Konzentrationen dieser Substanz vergleichend untersucht.

Es wurden signifikante Unterschiede in der Empfindlichkeit gegenüber Phosphono‐format beobachtet, aber keinerlei natürliche Resistenz. Dieses Ergebnis könnte bei einer evtl. klinischen Anwendung zur Behandlung der Taubenherpesvirus‐Infektion von Bedeutung sein.

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