Changes in plasma chemistry after drug‐induced liver disease or muscle necrosis in racing pigeons (Columba livia domestica)

Summary

Changes in plasma variables as a result of liver damage induced by ethylene glycol (group A) or D‐galactosamine (group B) and of muscle damage induced by doxycycline were compared.

Plasma bile acid concentration was both a specific and a sensitive indicator of liver disease. Another specific, but less sensitive indicator of liver disease was 7‐GT. Plasma AS AT activity was the most sensitive indicator of disease of the liver, but was not specific, since increased ASAT activities were also seen during muscle disease. ALAT activity was slightly more sensitive to liver damage than 7‐GT, but was also not specific, being increased also after muscle damage. Plasma GLDH activity was increased only as a result of extensive liver necrosis. AP activity was of no value for detecting liver disease in the pigeon.

CK activity was specific for muscle injury, though the activities of ALAT, ASAT and LD were also increased. Because of its long elimination half‐life, increased ALAT activity persisted for 9 days after muscle damage, whereas CK activity returned to reference values within 3 days.

LDH was a poor indicator of damage to liver and muscle, despite its relatively high tissue concentrations in both tissues. The rapid disappearance rate of LDH from plasma probably explains this observation.

Resume

Modifications de la composition chimique du plasma après administration de médicaments induisant des troubles hépatiques ou de la nécrose musculaire chez les pigeons voyageurs (Columba livia domestica)

Les modifications des constantes plasmatiques, consécutives à des lésions du foie induites par l'Ethylene glycol (groupe A) ou par la d‐galactoxamine (groupe B), ou consécutives des lésions du muscle induites par la doxycycline (groupe C), ont été étudiées et comparées chez le pigeon voyageur.

Zusammenfassung

Veränderungen chemischer Plasmawerte als Folge einer durch Therapeutika induzierten Leberkrankheit oder von Muskelnekrosen bei Reisetauben

(Columba livia domestica)

Veränderungen von Plasmaparametern als Folge der durch Aethylenglykol (Gruppe A) oder durch d‐Galactosamin (Gruppe B) verursachten Leberschäden wurden mit denjenigen bei durch Doxycyclin (Gruppe C) induzierten Muskelveränderungen verglichen.

Resumen

Cambios en el plasma sanguíneo en la hepatopatia inducida por farmacos o en la necrosis muscular en las palomas de carreras (Columba domestica)

Se compararon los cambios en los valores plasmáticos debidos a la lesión hepática producida por el etilen glicol (grupo A) o la D‐galactosamina (grupa B) y el daño muscular inducido por la doxiciclina.