ORGANOPHOSPHORUS COMPOUNDS. XXXVIII. SYNTHESIS OF DIALKYL PHOSPHATES OF 3-CHLORO-4-HYDROXY CARBOSTYRIL AND 3,4-DIHYDROXY-1-METHYLCARBOSTYRIL AS POTENTIAL ANTICHOLINESTERASES

Abstract

Trialkyl phosphites react with 3,3-dichloro-2,4-dioxocarbostyrils (1a, b) and 2,3,4-trioxo-1-methylcarbostyril (1c) to give dialkyl phosphates of types (4) and (9), respectively. Structures of the new products were established by analytical and spectroscopic (IR, ¹H NMR, ³¹P NMR, and MS) results. The anticholinesterase activity of compounds (4a), (4d), and (9a) was tested.