![Sample our Physical Sciences journals, sign in here to start your FREE access for 14 days]({"type":"image" , "src" : "/sda/110819/TOC-Subject-Sample-2021-Physical-Sciences.jpg"})
Abstract
The synthesis of methyl-bis(aminomethyl)phosphine oxide (Ia) is described starting from methyl-bis(chloromethyl)phosphine oxide (MBCPO) and using as an intermediate methyl-bis(phthalimidomethyl)phosphine oxide (II). The following substituted phthalimido derivatives have also been prepared: methyl-bis(4-nitrophthalimidomethyl)phosphine oxide (III), methyl-bis(4-aminophthalimidomethyl)phosphine oxide (IV), methyl-bis(4-benzamidophthalimidomethyl)phosphine oxide (V), methyl-bis(4-carboxy-phthalimidomethyl)phosphine oxide (VI) and its dicyclohexylammonium salt (VII). Methyl-bis(aminomethyl)phosphine oxide (Ia) is isolated and characterized as a dihydrochloride (I).