A kinetic model for simulation of blood coagulation and inhibition in the intrinsic path

Abstract

A mathematical simulation pathway for the generation of thrombin has been developed with various assumptions made of kinetic rate laws and their summation for reactions involving the activation of factors VIII, IX, X and V and protein C in the formation of thrombin. The object of the computational modelling study is to simulate the activation and inhibition of blood coagulation. The level of complexity and assumed parameters makes conclusions uncertain. However, an interesting outcome is that kinetic rates may show oscillation behaviour under particular high levels of protein C feedback inhibition. The model, which permits the assessment of the reaction over a broad range of conditions, would defy quantitative practical use, but could have predictive value as a qualitative descriptor of coagulation.