Construction of lumped-parameter cardiovascular models using the CellML language

Abstract

Lumped-parameter models are widely used by cardiovascular researchers in the analysis of the circulatory dynamics. However, portability and model exchange have always been a problem, with different researchers implement the model differently. To improve the situation, in this study, a group of lumped-parameter cardiovascular system models with different levels of complexity have been implemented using the CellML mark-up language. The models have been curated and made publicly available in the CellML model repository, and the purpose of this paper is to provide further technical details to support the usage of these models by the research community. The developed models are validated and tested under the OpenCell environment as part of the curation process. Simulation results agree well with typical published data on cardiovascular system response.

Keywords:

• Lumped-parameter model
• cardiovascular system
• numerical simulation
• CellML

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported by the European Commission's Framework 7 program [Grant number: FP7-ICT-2007–224495, euHeart: Personalised & Integrated Cardiac Care: Patient-specific Cardiovascular Modelling and Simulation for In Silico Disease Understanding & Management and for Medical Device Evaluation & Optimization].