Development of a flow simulator to study haemodynamic behaviour of natural and artificial blood vessels under physiologic flow conditions

Abstract

A new computer-controlled flow simulator has been designed to study the haemodynamic behaviour of natural and artificial blood vessels under physiologic flow conditions. The simulator can generate well characterized and fully developed laminar flow properties. It includes a unique perfusion case that imposes an axial tension on the vessel segment, and a commercial programmable pump to reproduce pulsatile flow rates. Response to high frequency commands was greatly attenuated and displayed a frequency dependent phase angle. Thus, for complex pulsating flow rates containing different frequency components, the system response was significantly distinct from the command. To reproduce physiologic waveforms, the transfer function of the whole system was determined for different amplitudes and frequencies of flow rate-excitations. Each input command was compared to the measured flow rate, and the values of the gain and phase angle were evaluated. If the desired flow rate was composed of a sum of n sine wave components, each has a frequency fj and an amplitude Aj, a corrected command signal was then reconstructed byamplifying the attenuated components and advancing those lagged in time. The corrected signal was finally applied as the new command to the pump. The results showed an excellent agreement with physiologic waveforms. Examples of different pulsatile flow experiments to investigate the effects of frequency, pressure, and wall elasticity are presented.