Sequential participation of glutathione and sulph‐hydryl (S) in reductive dechlorination of 2, 4‐di‐, and 2, 4, 5‐trichloro phenacyl chlorides by soluble fraction (105,000 x g) of chicken liver homogenate.

Abstract

The mode of reductive dechlorination of α‐chloroacetophenones, 2,4‐di‐, and 2,4,5‐trichloro phenacyl chlorides into respective acetophenone by soluble fraction (105,000 x g) from chicken liver homogenate has been investigated. The transformation involved the sequential participation of glutathione and a sulph‐hydryl. The phenacyl chloride first reacted with glutathione to yield the phenacyl glutathione, which in turn, in the presence of a sulph‐hydryl, was reduced enzymatically to produce the ketone, probably via a disulfide intermediate.

Key words:

• Metabolism
• Phenacyl chloride
• Glutathione
• Soluble fraction.