Publication Cover
Journal of Environmental Science and Health, Part B
Pesticides, Food Contaminants, and Agricultural Wastes
Volume 14, 1979 - Issue 4
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Original Articles

Metabolism of 2‐chloro‐N‐isopropylacetanilide (Propachlor) in the rat

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Pages 427-441 | Published online: 21 Nov 2008
 

Abstract

Eleven urinary metabolites from [14C]propachlor were either identified or characterized by mass spectrometry. Those identified were 2‐[S‐(N‐acetyl)cysteinyl]‐N‐isopropylacetanilide, 2‐(methylsulfonyl)‐acetanilide, 4'‐hydroxy‐2‐(methylsulfonyl)‐acetanilide, and 4'‐hydroxyacetanilide. Those characterized were N‐(l‐hydroxyisopropyl)‐2‐(methylsulfonyl) acetanilide and its glucuronide, the glucuronides of 4'‐hydroxy‐N‐isopropyl‐2‐(methylsulfonyl)acetanilide, N‐(l‐hydroxyisopropyl) aniline, 4'‐hydroxy‐2‐(methylsulfonyl)acetanilide, and either N‐(1‐hydroxy‐isopropyl) acetanilide or 2‐hydroxy‐N‐isopropylacetanilide.

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