Teratogenic evaluation of ethylene chlorhydrin (ECh, 2‐chlorethanol) in mice

Abstract

ECh administered intragastrically to pregnant CD‐1 mice from the 6th to the 16th day of gestation at a dose of 100 mg/kg produced a significant reduction in maternal weight gain and a decrease in fetal body weight and liver weight. A lower dose of 50 mg/kg had no consistent effect and a higher dose of 150 mg/kg was maternally lethal. Administration of ECh in the drinking water at doses of 16, 43, 77, or 227 mg/kg did not produce any adverse effects on maternal or fetal body weight, viability, or fetal anatomical development.

Key words:

• Teratology
• Mice
• Ethylene Chlorhydrin
• 2‐Chlorethanol

Notes

Disclaimer: This report has been reviewed by the Health Effects Research Laboratory, U.S. Environmental Protection Agency, and approved for publication. Mention of trade names or commercial products does not constitute endorsement or recommendation for use.