Effect and mechanism of action of methomyl and cypermethrin insecticides on kynurenine metabolizing enzymes of mouse liver

S.M. El‐Scwedy Departments of Applied Medical Chemistry and Pharmacology, Medical Research Institute, and Department of Biochemistry, Faculty of Medicine, Alexandria University, Egypt

M. A. Zahran Departments of Applied Medical Chemistry and Pharmacology, Medical Research Institute, and Department of Biochemistry, Faculty of Medicine, Alexandria University, Egypt

M.A. Zeidan Departments of Applied Medical Chemistry and Pharmacology, Medical Research Institute, and Department of Biochemistry, Faculty of Medicine, Alexandria University, Egypt

M.H. Mostafa Departments of Applied Medical Chemistry and Pharmacology, Medical Research Institute, and Department of Biochemistry, Faculty of Medicine, Alexandria University, Egypt

E.A. El‐Bassiouni Departments of Applied Medical Chemistry and Pharmacology, Medical Research Institute, and Department of Biochemistry, Faculty of Medicine, Alexandria University, Egypt

Abstract

The effect of methomyl and cypermethrin insecticides on the B₆‐dependent kynurenine hydrolase(KH) and kynurenine aminotransferase (KATE) was studied. These insecticides induced pronounced inhibition on the (KH) and (KATE) enzymes after single dose treatment. Repeated doses of methomyl induced inhibition on the (KH) and (KATE) activities, whereas repeated treatment with cypermethrin had no effect on the activities of these enzymes. In vitro methomyl inhibited (KH) and (KATE) enzymes at 10 M up to 10^‐3 M, through a competitive mechanism. Methomyl and cypermethrin are capable of causing alterations in the kynurenine metabolizing enzymes of mouse liver.

Key words:

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Effect and mechanism of action of methomyl and cypermethrin insecticides on kynurenine metabolizing enzymes of mouse liver

Information for

Open access

Opportunities

Help and information

Effect and mechanism of action of methomyl and cypermethrin insecticides on kynurenine metabolizing enzymes of mouse liver

Abstract

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature