Comparison of the delayed neurotoxicity of O‐methyl and O‐ethyl analogs of EPN, leptophos, and cyanofenphos

B. Magnus Francis Institute for Environmental Studies, Department of Veterinary Biosciences, School of Medicine, Department of Entomology, University of Illinois, Urbana, Illinois, 61801

Larry G. Hansen Institute for Environmental Studies, Department of Veterinary Biosciences, School of Medicine, Department of Entomology, University of Illinois, Urbana, Illinois, 61801

Robert A. Metcalf Institute for Environmental Studies, Department of Veterinary Biosciences, School of Medicine, Department of Entomology, University of Illinois, Urbana, Illinois, 61801

Robert L. Metcalf Institute for Environmental Studies, Department of Veterinary Biosciences, School of Medicine, Department of Entomology, University of Illinois, Urbana, Illinois, 61801

Abstract

Eight pairs of O‐methyl and O‐ethyl O‐(substituted‐phenyl) phenylphosphonothionates were evaluated with respect to their delayed neurotoxic activity in hens. O‐methyl compounds were in all cases more active than their O‐ethyl analogs. The neurotoxic potential of the O‐methyl phenylphosphonothionates was 2,5‐diCl >4‐NO₂ >2,4,5‐triCl and 2,4,6‐triCl >2,4‐diCl >2,5‐diCl‐4‐Br >4‐CN, when single oral doses were given. Both EPN‐ethyl and leptophos‐raethyl were more neurotoxic in multiple dermal than multiple oral dosing regimens. LD₅₀s for mice and flies were established.

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Comparison of the delayed neurotoxicity of O‐methyl and O‐ethyl analogs of EPN, leptophos, and cyanofenphos

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Comparison of the delayed neurotoxicity of O‐methyl and O‐ethyl analogs of EPN, leptophos, and cyanofenphos

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