Determination of the half life of fenthion in New Zealand white rabbits using three routes of administration

Abstract

The purpose of this research was to determine if the route of administration influenced the biological half life of fenthion, an organophosphorous insecticide. Twenty mg/kg fenthion was given to groups of New Zealand White Rabbits via the oral, subcutaneous and intravenous routes respectively. The distribution of fenthion in the blood of New Zealand rabbits followed an open two compartment model. There were no significant differences in the kinetic parameters (α , β , K₁₂, K₂₁, K_el) derived for the three different routes of administration. The biological half life of slightly over 11 hours, did not differ significantly with the route of administration.

Key words:

• Fenthion
• Routes of Administration
• Biological Half Life