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Publication Cover
Journal of Environmental Science and Health, Part B
Pesticides, Food Contaminants, and Agricultural Wastes
Volume 26, 1991 - Issue 4
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Original Articles

In vitro brain acetylcholinesterase response among three inbred strains of mice to monocrotophos

J.V. Rao Toxicology Unit, Biology Division, Indian Institute of Chemical Technology, Hyderabad, 500 007, India
,
A.N. Swamy Toxicology Unit, Biology Division, Indian Institute of Chemical Technology, Hyderabad, 500 007, India
&
S. Yamin Toxicology Unit, Biology Division, Indian Institute of Chemical Technology, Hyderabad, 500 007, India
Pages 449-458 | Received 05 May 1990, Published online: 13 Feb 2011
 
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Abstract

The strain differences in the neurotoxic potential of monocrotophos (HCP) were assessed by determining the inhibition of brain acetylcholinesterase (AChE) in BALB/cAnN, DBA/2J and C57BL/6J in vitro. MCP being a competitive inhibitor for AChE, alters the Km values widely among these inbred strains. Comparatively least alterations in Km were found in BALB/cAnN and maximum in DBA/2J. Based on the Ki values DBA/2J was found to be the most sensitive strain to HCP inhibition followed by C57BL/6J and BALB/cAnN.

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