Terms Index
20(S)-ginsenoside Rh1, 222
23-hydroxybetulinic acid, 293
25 dihydroxyvitamin D3, 160
5-Fluorouracil, 244
Absorption, 51, 324, 310
Acute renal failure, 266
Amphotericin B, 76
Analytical, 62, 66, 67, 68, 69, 72, 74, 73, 75, 76, 77, 80, 81, 82, 84, 85, 115, 119, 169, 181, 186, 198, 200, 201, 204, 218, 219, 243, 245, 255, 258, 259, 268, 285, 318
Andrographis paniculata, 245
Andrographolide, 160, 298
Anthraquinones, 220
Anti-inflammation, 127
Aralia continentalis Heme oxygenase-1, 153
Artemisinin, 154
Arthritis, 323
Atomoxetine, 247
Baculovirus expression system, 104
Baicalein, 56, 148
Baicalin, 148, 225
Belotecan, 271
Berberine, 148, 223
Biapenem, 288
Biliary Drainage Models, 294
Bioaccumulation, 117
Bioavailability, 52, 62, 71, 74, 80, 86, 87,115, 116, 118, 122, 136, 231, 245, 266, 269, 272, 276, 290, 291, 324
Bioequivalence, 272
Biomarkers, 67, 173
bisphenol A, 176
Blood-Brain Barrier, 292, 322
Brain Transport, 292
Caco-2, 88, 148, 149
Caco-2 Cells, 339
Caffeic Acid, 59
Cardamonin, 218
Carisoprodol, 234
Cat, 92
Cell Lysate, 75
Chemotherapy, 293
Cinnamic acid, 89
Classification Mutagenicity, 184
Clearance Prediction, 101, 176, 182, 183, 226, 276, 319, 335
Clinical Assessment, 111
Computed Tomography, 99
Conjugation Reactions and Enzymes, 59, 90, 159, 176, 193, 196, 211, 225, 327
Coptidis Rhizoma, 194
Coumarin, 97
Cryptotanshinone, 52
Cyanin chloride, CYP1A1, 95
Cynomolgus Monkey, 120, 221, 303
CYP enzymes, 105
CYP2A13, 214
CYP2D6, 98
CYP3A4, 160
Cytochrome P450, 46, 49, 50, 55, 58, 60, 65, 66, 92, 93, 94, 95, 97, 100, 101, 102, 105, 107, 108, 109, 110, 112, 130, 131, 135, 137, 138, 143, 145, 151, 152, 155, 156, 157, 158, 160, 161, 166, 167, 177, 178, 183, 185, 186, 187, 188, 189, 190, 193,203, 204, 211, 212, 214
Daidzein, 255
Daidzin, 255
Danggui, 156
Danshen Extract, 105
Dealkylation Tool and Mass Defect Filter, 205
Dertromethorphan, 84
Dextrophan, 84
Diet, 109
Differences in metabolism (species, gender, age, diseases), 45, 49, 60, 108, 109, 110, 112,166, 176, 203, 227, 235, 236, 237, 238, 261, 323
Disposition, 53, 114, 116, 117, 118, 126, 130, 182, 219, 244, 251, 252, 255, 265, 267, 270, 295, 299, 300, 314, 325, 328, 336, 273, 320, 321, 327
Distribution, 119
DNA Methylation, 167
Double-peak Phenomenon, 294
Doxazosin, 72
Drug Discovery and Development, 67, 69, 88, 110, 115, 118, 122, 124, 125, 126, 127, 147, 171, 177, 180, 181, 184, 186, 187, 210, 251, 259, 263, 265, 267, 270, 273, 291, 315, 319
Drug Interaction, 44, 55, 63, 65, 66, 131, 132, 133, 134, 135, 136, 137, 138, 143, 145, 146, 151, 152, 155, 157, 158, 159, 160, 194, 228, 229, 252, 259, 286, 300, 309, 320, 324, 330, 336, 339
Drug-drug Interactions, 223
Early Atherosclerosis, 174
Effective Components, 119
Elimination, 52
Enzyme Induction, 46, 55, 58, 93, 107, 108, 137, 138, 143, 145, 153, 154, 155, 177, 189, 226, 304
Enzyme Inhibition/Inactivation, 44, 55, 92, 93, 133, 134, 135, 143, 145, 151, 152, 156, 157, 158, 159, 160, 187, 193, 215, 226
Enzyme Kinetics, 183
Estradiol, 159
Excretion, 299
Extrahepatic metabolism, 91, 215, 196, 97, 225
Fenofibrate, 221
First-pass elimination, 223
Flavin-containing Monooxygenase 3, 227
Folic Acid Induced Acute Renal Failure, 271
Forsythiaside, 74
Fucoidan, 163
Furan, 169
Gallic acid, 83
Gamma-Hydroxybutyrate (GHB), 252
GC/MS, 174
GC/TOF/MS, 173
Gemfibrozil, 303
Gemifloxacin, 289
Gene Expression and Regulation, 46, 50, 55, 57, 58, 61, 95, 112, 153, 162, 163, 164, 165, 166, 168, 179, 227, 232, 239, 240, 304, 314, 331, 337
Genomics/Metabonomics/Proteomics, 50, 57, 60, 61, 169, 171, 172, 173, 174, 231, 239, 240
Ger-Gen-Chin-Lien Tang, 140
Ginsenoside Rb1, 304
Global Detection, 81
Glycyrrizic acid, 149
GSH trapping, 200
Half life, 124
Hamster, 174
Harmine Hydrochloride, 242
Hematoporphyrin, 264
Heme Oxygenase-1, 304
Hepatic Blood Flow, 120
Hepatic Transporters, 317
Hepatic Uptake Biliary Excretion, 315
Hepatocytes, 49, 53, 99, 115, 128, 155, 167, 178, 180, 211, 323, 335
Herbal Drugs, 81
Herb-drug Interaction, 105
High Performance Liquid Chromatography, 288
High Throughput Techniques, 65, 69, 78, 198, 204, 181, 200, 205, 251, 258, 283, 284
HPLC, 75, 76, 83, 289
Huang-Qin Tang, 339
HUVECs, 75
Hypercholesterolemia, 174
In Silico, 131, 133, 184
In Situ Closed Loop Models, 294
In Vitro Techniques, 48, 51, 63, 65, 66, 67, 83, 85, 88, 91, 93, 104, 131, 146, 147, 148, 152, 155, 156, 159, 167, 171, 179, 180, 186, 196, 198, 201, 210, 218, 256, 291, 309, 311
In Vivo, 59, 83
Inflammation, 321
Inhibitor, 293
Integrated LC-MS Metabonomics, 206
Intestinal Absorption, 294, 333
Isoflavone Pueraria lobata, 255
Isoline, 216
Itraconazole, 76
Ketoprofen, 51
KR-33028, 254
LC-(ESI)-IT-TOF/MS, 82
LC/MS, 59, 216
LC/MS/MS, 70, 74, 81, 84, 120, 224
Ligand Binding, 175
Liposome, 124
Liver, 56
Liver toxicity, 188
Lung Cancer, 264
Mai-Luo-Ning Injection, 81
Mass Spectrometry, 154, 170
Mechanisms of Xenobiotic Toxicities, 163, 169, 189, 208, 322
Metabolic Profiling, 44, 45, 48, 59, 60, 81, 101, 110, 111, 114, 169, 170, 173, 176, 195, 197, 198, 199, 200, 201, 202, 204, 205, 206, 207, 210, 211, 212, 226, 245, 259, 311
Metabolism, 44, 45, 47, 49, 56, 63, 66, 79, 80, 85, 91, 92, 93, 108, 109, 110, 111, 112, 119, 131, 145, 151, 152, 170, 177, 178, 183, 186, 187, 188, 189, 195, 196, 197, 200, 201, 202, 203, 208, 209, 210, 211, 212, 213, 214, 215, 216, 218, 221, 222, 223, 224, 228, 232
Metabolite Profiling, 56
Metabolite Synthesis, 90
Metabolites, 255
Metabolites Analysis, 81
Metabonomics, 173, 174
Metformin, 336
Methotrexate, 139, 140, 141, 330
Methyl Protodioscin,
Methylphenidate, 247
Microdialysis, 247
MIST, 111
MMP-9, 292
MRPs, 330
Multidrug Resistance-associated Proteins, 139
Multivariate statistical analysis, 174
Mycotoxin, 91
Myotoxicity, 303
Nano-particle micelle of doxorubicin, 295
Nanoparticles, 264
Natural products, 156
Neurotransmitter, 247
Nicotine, 170
Non-P450 phase I enzymes, 49, 168, 212, 225, 227
Nucleoside Transporter, 325
Nude mice, 244
Oral Drug Absorption, 51
Organic anion transporters, 139
Oridonin, 71
Oxidative Stree, 292
P450 Inhibitor, 223
Paeoniflorin, 149, 257
Paracetamol, 84, 103
Paraquat, 117
Peroxidases, 188
P-glycoprotein, 75, 333, 339
P-gp, 293
Pharmacogenetics, 57, 61, 98, 101, 227, 228, 231, 232, 235, 236, 237, 238, 240, 262, 326, 329, 340,
Pharmacokinetic Study of Breviscapine Naristilla and Nasal Gelata, 297
Pharmacokinetics, 89, 121, 150, 222, 234, 241, 255, 271, 289, 290, 293, 296
Pharmacokinetics and Pharmacodynamics, 52, 53, 60, 62, 63, 68, 71, 72,80, 88, 98, 115, 121, 123, 139, 144, 147, 151, 175, 181, 182, 185, 215, 220, 228, 231, 235, 236, 237, 238, 242, 243, 244, 246, 249, 250, 252, 253, 254, 256, 257, 259, 260, 262, 263, 265, 267, 270, 273, 275, 277, 278, 280, 2
Phase I, 56, 59
Phase II, 56, 59
Phenytoin, 142
Physiologically based pharmacokinetic (PBPK) models, 182
PK/PD modeling, 248
Plasma, 70, 268
PLC Danshen Injection, 290
Polyethylene glycol, 124
Polymers, 244
Polymorphism, 258
Poly-organophosphazene drug delivery system, 253
Prodrug, 241
Protein Binding, 122
Protein Precipitation, 70
Puerarin, 255
Pyranocoumarins, 156
Pyrrolizidine Alkaloid, 216
Quantification, 68
Radix Astragali, 173
Radix Paeoniae Alba, 257
Radix Paeoniae Rubra, 257
Ramulus Cinnamomi, 89
Rat, 56, 59, 290
Reactive Metabolite Identification, 204
Reactive Metabolites, 198
Receptor Binding Kientic Model, 248
Receptor Occupancy, 248
Receptors/nuclear receptors, 95, 108, 137, 164, 175, 263, 273, 304, 306, 308, 337
Renal Secretion, 271
Repeated Administration, 333
Reserpine, 150
Rhodamine 123, 75
Safety Testing, 111
Salt, 337
Scutellariae Radix, 121
Shaoyao-Gancao-Tang, 149
Shengmai injection, 82
Signal Transduction, 128
Sijunzi Decoction, 150
Sophorae Flos decoction, 266
Spontaneously Hypertensive Rats, 173, 333
Stereoselective Metabolism, 44, 187, 250, 310, 311
Structural Identification, 81
Substrate Recognition, 333
Sudoxicam, 208
Suppository, 242
Tanshinone, 105, 292
Targeting, 264
Tea Ployphenols, 103
Time-dependent Pharmacokinetics, 154
Tissue Distribution, 52, 121, 220
Tissue Plasminogne Activator, 124
Total Panax Notoginsenoside(TPNs), 119
Toxicity, 170
Toxicokinetics, 194, 279
Traditional Chinese Medicine, 82, 89, 194, 299, 300
Traditional Medicine, 83
Transporters, 53, 56, 88, 122, 123, 136, 139, 140, 141, 142, 146, 162, 164, 171, 177, 229, 230, 252, 310, 312, 313, 315, 318, 320, 322, 323, 324, 326, 327, 329, 330, 331, 334, 336, 340, 338
Tropisetron, 70
Uric acid, 338
Urine, 268
Xenobiotic Toxicities, 209
Xiexin Decotion, 299, 300