Raman spectroscopy using plasmonic and carbon-based nanoparticles for cancer detection, diagnosis, and treatment guidance. Part 2: Treatment

Abstract

Raman spectroscopy and surface-enhanced raman scattering (SERS) have the potential to improve the detection and monitoring of various diseases, particularly cancer, with or without the support of multifunctional active nanosystems. This review is focused on the recent advances that have made Raman a major tool for treatment guidance for surgical tumor resection or for analytical monitoring of various therapies, such as photodynamic therapy, photothermal therapy, and drug delivery. The potential of Raman spectroscopy and nanosytems to further improve cancer treatments is also discussed.

Keywords:

• Cancer
• treatment
• Raman
• SERS
• plasmonic
• carbonaceous
• nanoparticles
• drug
• PDT
• PTT

Acknowledgements

We are very grateful to Emily Davis and Dr. Daniel Casciano for the review and assistance with the technical editing of this manuscript.

Disclosure statement

The authors report no conflicts of interest.

Additional information

Funding

We acknowledge partial support from the Center for Advanced Surface Engineering, under the National Science Foundation Grant No. IIA-1457888 and the Arkansas EPSCoR Program, ASSET III. This research was funded by the Food and Drug Administration (FDA), contract HHSF223201210189C. However the information contained herein represent the position of the author(s) and not necessarily that of the FDA. This research was supported by a grant from the Arkansas Breast Cancer Research Program and the University of Arkansas for Medical Sciences.